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KMID : 0361519990100010065
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Korean Journal of Psychopharmacology
1999 Volume.10 No. 1 p.65 ~ p.70
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Effect of Clozapine on Plasma Prolactin Levels in Schizophrenic Patients
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Kim Chul-Eung
Kang Min-Hee
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Abstract
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Objective：The purpose of this study was to investigate the effect of clozapine on serum prolactin concentration in schizophrenic patients.
Method：The subjects composed of 3-schizophrenic patients with hyperprolactinemia after treatment with risperidone and 9-tratment resistant chronic schizophrenic patients. Serum prolactin concentration was measured by radioimmunoassay method before clozapine administration and after 1 and 4 week of treatment. Data were analysed by the SAS program. Statistical methods employed was Wilcoxon-sign rank test.
Results：1) Clozapine had improving effect on 3 risperidone-induced hyperprolactinemic patients. 2) Clozapine did not have significant effect on serum prolactin levels in 9-tratment resistant chronic schizophrenic patients.
Conclusion：Clozapine has minimal effects on serum prolactin levels in schizophrenic patients as well as improving effect on antipsychotics-induced hyperprolactinemia. We recommend atypical antipsychotcs such as clozapine as alternative treatments for complicated hyperprolactinemia induced by other antipsychotics.
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KEYWORD
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Schizophrenia, Prolactin, Clozapine,
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